Fragment based drug discovery and x ray crystallography topics in current chemistry vol 317 9783642275395 medicine health science books amazoncom. Acknowledgements the hsp90 project was a substantial effort which involved most members of vernalis at one time or another of particular significance was the contributions of xavier barril who provided the inspirational contributions in virtual screening and molecular modelling and of ben davis who remains the principal driver of the development of the nmr techniques and fragment screening . Fragment based chemistry has caused a revolution in drug discovery we anticipate that this will spread although it is unlikely to be the only approach used by chemists in drug discovery . Fragment based lead discovery fbld also known as fragment based drug discovery fbdd is a method used for finding lead compounds as part of the drug discovery process fragments are small organic molecules which are small in size and low in molecular weight it is based on identifying small chemical fragments which may bind only weakly to the biological target and then growing them or . Fragment screening offers an alternative to traditional screening for discovering new leads in drug discovery programs this paper describes a fragment screening methodology based on high throughput x ray crystallography the method is illustrated against five proteins p38 map kinase cdk2 thrombin ribonuclease a and ptp1b
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