Progress in drug metab v 9 progress in drug metabolism metabolism and toxicity of drugs two decades of progress the science of drug metabolism and pharmacokinetics dmpk has developed significantly over the past 20 years and its functional role in todays pharmaceutical industry has matured to. Cytochrome p450 p450 enzymes are ancient electron transfer chain system of remarkable biological importance microsomal p450 enzymes are the p450 attached to endoplasmic reticulum which in humans are critical for bodys defenses against xenobiotics by mediating their metabolism and cell signal . Dmd presents important research in pharmacology and toxicology and is a valuable resource in drug design drug metabolism drug transport expression of drug metabolizing enzymes and transporters and regulation of drug metabolizing enzyme and transporter gene expression. Drug metabolism and pharmacokinetics dmpk is an official online journal of the japanese society for the study of xenobiotics jssx and it replaces the jssxs former journal xenobiotic metabolism and disposition the journal will accept original submissions in english on the understanding that the work is unpublished and is not being considered for publication elsewhere. Current drug metabolism aims to cover all the latest and outstanding developments in drug metabolism pharmacokinetics and drug disposition the journal serves as an international forum for the publication of full length mini review research articles and guest edited issues in drug metabolism
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