In primates including women and in rodents natural killer lymphocytes nk cells have a unique relationship with the decidualizing uterus implantation sites from genetically modified and transplanted mice have proven useful models for understanding potential mechanisms involved in recruitment activation and functions of human cd56 bright uterine unk cells. Nk cells are known to differentiate and mature in the bone marrow lymph nodes spleen tonsils and thymus where they then enter into the circulation nk cells differ from natural killer t cells nkts phenotypically by origin and by respective effector functions often nkt cell activity promotes nk cell activity by secreting interferon gamma. This schematic figure shows the possible sources of the uterine natural killer cells unk 1 unk cells may proliferate in the of the decidua as shown by ki67 expression 2 peripheral nk cells may influx into uterus and differentiate here to unk cells 3 cd34 precursor cells localized in the basal layer may be a source of unk cells. Immunity article trained memory of human uterine nk cells enhances their function in subsequent pregnancies moriyagamliel1 debragoldman wohl2 batyaisaacson1 chamutalgur1 natanstein1 rachelyamin1 michaelberger1 myriam grunewald 3eli keshet yoach rais4 chamutal bornstein5 eyal david 5adam jelinski iris eisenberg2 caryn greenfield 2arbel ben david tal imbar 2ronit gilad ronit . Immunity article natural killer cells promote fetal development through the secretion of growth promoting factors binqing fu125 yonggang zhou125 xiang ni125 xianhong tong3 xiuxiu xu12 zhongjun dong4 rui sun12 zhigang tian12 and haiming wei126 1institute of immunology and the cas key laboratory of innate immunity and chronic disease school of life science and medical center
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